OP3. Developing a urinary biomarker panel for monitoring LUPUS NEPHRITIS disease activity
نویسندگان
چکیده
منابع مشابه
Urinary neutrophil gelatinase-associated lipocalin as a novel biomarker for disease activity in lupus nephritis.
OBJECTIVES Clinical and laboratory markers in current use have limited specificity and sensitivity for predicting the development of renal disease in lupus patients. In this longitudinal study, we investigated whether urinary neutrophil gelatinase-associated lipocalin (uNGAL) predicts active nephritis and renal flares in lupus patients with and without a history of biopsy-proven lupus nephritis...
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Introduction Up to 80% of children with Juvenile Systemic Lupus Erythematosus (JSLE) develop lupus nephritis (LN) (1), with the 5-year renal survival rate varying between 44-94% (2-4). Conventional markers of JSLE disease activity fail to adequately predict impending LN flares (5), with significant renal involvement (class III, IV or V LN) known to occur with low level proteinuria (6). Cross-se...
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Lupus nephritis (LN) is one of the most severe manifestations of systemic lupus erythematosus (SLE), which is associated with significant morbidity and mortality of SLE patients. The pathogenesis of LN involves multiple factors, including genetic predisposition, epigenetic regulation and environmental interaction. Over the last decade, omics-based techniques have been extensively utilized for b...
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This study aims to explore the clinical value of urine TWEAK/Fn14 mRNA in lupus nephritis (LN) patients. Thirty one SLE (Systemic Lupus Erythematosus) patients with or without active LN and another 10 healthy controls were recruited. LN activity was assessed by SLE Disease Activity Index. Urinary expression of TWEAK, Fn14 and MCP-1 at the mRNA level was measured by RT-PCR. Urinary expression of...
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Renal involvement is common in systemic lupus erythematosus. Early diagnosis of lupus nephritis (LN), allowing the instigation of appropriate therapy, remains an important clinical challenge. Current biomarkers in clinical practice are less than ideal, lacking both sensitivity and specificity. In the previous issue of Arthritis Research & Therapy, Schwartz and colleagues demonstrated the potent...
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ژورنال
عنوان ژورنال: Rheumatology
سال: 2015
ISSN: 1462-0332,1462-0324
DOI: 10.1093/rheumatology/keu492